Alternative Therapy for Migraines: Ozone Therapy  

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Case study report date: 08/04/2025

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Patient information: A 51 year old female. 60 kgs in weight. Attended Leicester Ozone Clinic on 19 Nov 2024 and she remains on maintenance therapy until now. 

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Main symptoms at presentation: 

• Severe chronic migraines, on average every other day. Migraines are severely interfering with her work and her quality of life.

• Bowel issues, most likely IBS/SIBO

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Past illnesses: 

• None significant. 

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Prescription medication: 

• Eletriptan as needed for migraine but not effective.

• Propranolol for 2 years (2000 - 2002), not effective. 

• Topiramate was used for 1 week but she had to stop it because of side effects

• Botox: Tried botox privately every 3 months (31 points injected) from 2028 until 2021. Botox reduced migraine from 20 per month down to 4-5 per month. The loss of effect coincided with receiving the first dose of the covid jab.  

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Diet and supplements: Various diets to help with bowel symptoms. One diet she tried where she stopped gluten and dairy for 6 months. She also stopped all medication. The diet worked for 4 months then stopped working.  

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COVID-19 vaccination status: Vaccinated.

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Timeline of Events and therapies received prior to attending Leicester Ozone Clinic:

• In the past she tried maximum medical therapy including Botox injections with limited effect. 

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Therapy received from Leicester Ozone Clinic and therapeutic response: 

• 19 Nov 2024: First attendance at Leicester Ozone Clinic. Ozone therapy using Ozonated Saline method was commenced at weekly intervals for 5 doses. After a break of one month (Christmas period) she resumed her therapy at a fortnightly interval. Therapy continued to the date of this report. As of the 8th of April 2025, she received a total of 12 sessions of ozone therapy.

•  From the 4th dose onwards she started to feel that the frequency and the severity of the migraine is getting less and the effect started to become more noticeable with increasing number of therapies. At around the 10th session she was hardly having any migraines attacks, and if they occur they are milder and have clear triggers e.g stress. 

• 5 Mar 2025: High dose vitamin B2 drip was given after her ozone infusion (the Migraine Drip) to see if this can have an added effect on her migraine management, which is already very good. Oral B2 is endorsed by NICE. 

• 2 Apr 2025: The B2 drip in combination with ongoing ozone therapy almost completely abolished migraine and she decided to have another drip before considering oral supplementation as endorsed by NICE. 

• 16 Apr 2025: Came for ozone therapy. She reported one migraine in the past 2 weeks since her last ozone. Also reported that in the last 3 months she had only 2 bad migraines and that when she has a migraine now she does not need to take painkiller generally. 

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